Publications

Research in Dr. Wemmie's Laboratory has led to the publication of the following journal articles:

• Rapid acquisition strategy for functional T1ρ mapping of the brain. Johnson CP, Heo HY, Thedens DR, Wemmie JA, Magnotta VA. Magn Reson Imaging. 2014 Nov;32(9):1067-77. doi: 10.1016/j.mri.2014.07.010. Epub 2014 Aug 2. PMID: 25093630. 
• The bed nucleus of the stria terminalis is critical for anxiety-related behavior evoked by CO2 and acidosis. Taugher RJ, Lu Y, Wang Y, Kreple CJ, Ghobbeh A, Fan R, Sowers LP, Wemmie JA. J Neurosci. 2014 Jul 30;34(31):10247-55. doi: 10.1523/JNEUROSCI.1680-14.2014. PMID: 25080586.
• Drug abuse and the simplest neurotransmitter. Kreple CJ, Lu Y, LaLumiere RT, Wemmie JA. ACS Chem Neurosci. 2014 Sep 17;5(9):746-8. doi: 10.1021/cn500154w. Epub 2014 Jul 23. PMID: 25054738.
• Acid-sensing ion channels contribute to synaptic transmission and inhibit cocaine-evoked plasticity. Kreple CJ, Lu Y, Taugher RJ, Schwager-Gutman AL, Du J, Stump M, Wang Y, Ghobbeh A, Fan R, Cosme CV, Sowers LP, Welsh MJ, Radley JJ, LaLumiere RT, Wemmie JA. Nat Neurosci. 2014 Aug;17(8):1083-91. doi: 10.1038/nn.3750. Epub 2014 Jun 22. PMID: 24952644.
• Protons are a neurotransmitter that regulates synaptic plasticity in the lateral amygdala. Du J, Reznikov LR, Price MP, Zha XM, Lu Y, Moninger TO, Wemmie JA, Welsh MJ. Proc Natl Acad Sci U S A. 2014 Jun 17;111(24):8961-6. doi: 10.1073/pnas.1407018111. Epub 2014 Jun 2. PMID: 24889629.
• Evaluation of activity-dependent functional pH and T1ρ response in the visual cortex. Heo HY, Wemmie J, Thedens D, Magnotta VA. Neuroimage. pii: S1053-8119(14)00063-9. [Epub ahead of print] PMID: 24486980, Jan 2014.
• Regulator of G-protein signaling 6 (RGS6) promotes anxiety and depression by attenuating serotonin-mediated activation of the 5-HT(1A) receptor-adenylyl cyclase axis. Stewart A, Maity B, Wunsch AM, Meng F, Wu Q, Wemmie JA, Fisher RA. FASEB J. 28(4):1735-44. PMID: 24421401, April 2014.
• Acid-sensing ion channels 1a (ASIC1a) inhibit neuromuscular transmission in female mice. Urbano FJ, Lino NG, González-Inchauspe CM, González LE, Colettis N, Vattino LG, Wunsch AM, Wemmie JA, Uchitel OD. Am J Physiol Cell Physiol. 15;306(4):C396-406. Epub 2013 Dec 11. PMID: 24336653, Feb 2014.
• PRICKLE1 interaction with SYNAPSIN I reveals a role in autism spectrum disorders. Paemka L, Mahajan VB, Skeie JM, Sowers LP, Ehaideb SN, Gonzalez-Alegre P, Sasaoka T, Tao H, Miyagi A, Ueno N, Takao K, Miyakawa T, Wu S, Darbro BW, Ferguson PJ, Pieper AA, Britt JK, Wemmie JA, Rudd DS, Wassink T, El-Shanti H, Mefford HC, Carvill GL, Manak JR, Bassuk AG. PLoS One. 3;8(12):e80737. eCollection 2013. PMID: 24312498, Dec 2013.
• Localization and behaviors in null mice suggest that ASIC1 and ASIC2 modulate responses to aversive stimuli. Price MP, Gong H, Parsons MG, Kundert JR, Reznikov LR, Bernardinelli L, Chaloner K, Buchanan GF, Wemmie JA, Richerson GB, Cassell MD, Welsh MJ. Genes Brain Behav.13(2):179-94. Epub 2013 Dec 30. PMID: 24256442, Feb 2014.
• Functional t1ρ imaging in panic disorder. Magnotta VA, Johnson CP, Follmer R, Wemmie JA. Biol Psychiatry. 1;75(11):884-91. Epub 2013 Oct 21. PMID: 24157339, Jun 2014.
• Acid-sensing ion channels in pain and disease. Wemmie JA, Taugher RJ, Kreple CJ. Nat Rev Neurosci, 14(7):461-471, PMID: 23783197, Jun 2013.
• Disruption of the non-canonical Wnt gene PRICKLE2 leads to autism-like behaviors with evidence for hippocampal synaptic dysfunction. Sowers LP, Loo L, Wu Y, Campbell E, Ulrich JD, Wu S, Paemka L, Wassink T, Meyer K, Bing X, El-Shanti H, Usachev YM, Ueno H, Manak RJ, Shepherd AJ, Ferguson PJ, Darbro BW, Richerson GB, Mohapatra DP, Wemmie JA, Bassuk AG. Mol Psychiatry, PMID: 23711981, May 2013.
• Fear and panic in humans with bilateral amygdala damage. Feinstein JS, Buzza C, Hurlemann R, Follmer RL, Dahdaleh NS, Coryell WH, Welsh MJ, Tranel D, Wemmie JA. Nat Neurosci, 16(3):270-2, PMID: 23377128, Mar 2013.
• Acid-sensing ion channel 1: a novel therapeutic target for migraine with aura. Holland PR, Akerman S, Andreou AP, Karsan N, Wemmie JA, Goadsby PJ. Ann Neurol, 72(4):559-63, PMID: 23109150, Oct 2012.
• Detecting activity-evoked pH changes in human brain. Magnotta VA, Heo HY, Dlouhy BJ, Dahdaleh NS, Follmer RL, Thedens DR, Welsh MJ, Wemmie JA. Proc Natl Acad Sci USA, 109(21):8270-3, PMID: 22566645, May 2012.
• Neurobiology of panic and pH chemosensation in the brain. Wemmie JA. Dialogues Clin Neurosci, 13(4):475-83, PMID: 22275852, 2011.
• Expressing acid-sensing ion channel 3 in the brain alters acid-evoked currents and impairs fear conditioning. Vralsted VC, Price MP, Du J, Schnizzler M, Wunsch AM, Ziemann AE, Welsh MJ, Wemmie JA. Genes Brain Behav, 10(4):444-50, PMID: 21324060, Mar 2011.
• Mutations in prickle orthologs cause seizures in flies, mice, and humans. Tao H, Manak JR, Sowers L, Mei X...Wemmie J, Ueno N, Bassuk AG. Am J Hum Genet, 88(2):138-49, PMID:21276947, Feb 2011.
• ASIC1 and ASIC3 play different roles in the development of hyperalgesia after inflammatory muscle injury. Walder RY, Rasmussen LA, Rainier JD, Light AR, Wemmie JA, Sluka KA. J Pain, 11(3):210-8, PMID: 20015700, Mar 2010.
• The amygdala is a chemosensor that detects carbon dioxide and acidosis to elicit fear behavior. Ziemann AE, Allen JE, Dahdaleh NS, Drebot II, Corvell MW, Wunsch AM, Lynch CM, Faraci FM, Howard MA 3rd, Welsh MJ, Wemmie JA. Cell, 139(5):1012-21, PMID: 19945383, Nov 2009.
• Stereotactic atlas-based depth electrode localization in the human amygdala. Ova H, Kawasaki H, Dahdaleh NS, Wemmie JA, Howard MA 3rd. Stereotact Funct Neurosurg, 87(4):217-28, PMID: 19556831, Jun 2009.
• Acid-sensing ion channel-1a in the amygdala, a novel therapeutic target in depression-related behavior. Coryell MW, Wunsch AM, Haenfler JM, Allen JE, Schnizler M, Ziemann AE, Cook MN, Dunning JP, Price MP, Rainier JD, Liu Z, Light AR, Langbehn DR, Wemmie JA. J Neurosci, 29(17):5381-8, PMID: 19403806, Apr 2009.
• Oxidant regulated inter-subunit disulfide bond formation between ASIC1a subunits. Zha XM, Wang R, Collier DM, Snyder PM, Wemmie JA, Welsh MJ. Proc Natl Acad Sci USA, 106(9):3573-8, PMID: 19218436, Mar 2009.
• The cytoskeletal protein alpha-actinin regulates acid-sensing ion channel 1a through a C-terminal interaction. Schnizler MK, Schnizler K, Zha XM, Hall DD, Wemmie JA, Hell JW, Welsh MJ. J Biol Chem, 284(5):2697-705, PMID: 19028690, Jan 2009.
• Restoring Acid-sensing ion channel-1a in the amygdala of knock-out mice rescues fear memory but not unconditioned fear responses. Coryell MW, Wunsch AM, Haenfler JM, Allen JE, McBride JL, Davidson BL, Wemmie JA. J Neurosci, 28(51):13738-41, PMID: 19091964, Dec 2008.
• Seizure termination by acidosis depends on ASIC1a. Ziemann AE, Schnizler MK, Albert GW, Severson MA, Howard MA 3rd, Welsh MJ, Wemmie JA. Nat Neurosci, 11(7):816-22, PMID: 18536711, Jul 2008.